Axio Tamoxiplex

Often referred to as an anti-estrogen, Tamoxifen Citrate is actually both an antagonist and agonist. This means it will act as an anti-estrogen in certain areas of the body while acting as an estrogen in other areas.

It is a medication that is used by many anabolic steroid users, but it is not a steroid. This is a drug steroid users will sometimes use during steroid use to help with estrogenic related side effects brought on by specific steroids. However, it is most commonly used during Post Cycle Therapy (PCT). 

For the anabolic steroid user the positive effects of Tamoxifen Citrate can be seen both during and post anabolic steroid use with post use being primary. Tamoxifen Citrate does not lower serum estrogen levels, but it will bind to the receptors in the chest preventing the estrogen from binding. It will not do a lot for water retention if that is an issue. It is also not enough gynecomastia protection for all men, but that depends on how high estrogen levels go as well as genetics. If more or stronger protection is needed Aromatase Inhibitors (AI’s) are recommended. 

We then have the testosterone stimulating effects of Tamoxifen Citrate. This is by far the most important effect for the anabolic steroid user. When we use anabolic steroids we suppress our natural testosterone production, and this will occur regardless of the steroids used. This is why almost all steroid cycles include exogenous testosterone so that the negative feedback doesn’t cause a low testosterone level. Once steroid use is complete something is then needed to jump start testosterone production. It will occur on its own, but it will be slow and Tamoxifen can both speed it up and make it more efficient. 

For the breast cancer patient the effects of Tamoxifen Citrate are perhaps even more straightforward than they are for the anabolic steroid user. Estrogen attaches and feeds the cancer, but Tamoxifen Citrate prevents it from attaching and starves the cancer. This is a simple yet effective means of treatment. This is not the only drug used in treatment; commonly treatment will begin with an AI and then will be switched to a SERM like Tamoxifen Citrate. It is also sometimes used as a preventative measure in those that have a strong family history of breast cancer.

Headaches, upset stomach, hot flashes, vaginal Itching, bleeding, discharge or discomfort, rash, decreased white blood cell count, endometrial changes, increased triglyceride levels, pulmonary embolism.

For the purpose of breast cancer treatment there are six Tamoxifen Citrate plans that encompass both male and female treatment. In any of the six plans doses normally fall in the 10-20mg twice per day range. A full 40mg per day (20mg twice per day) is very common during the first stage of Tamoxifen Citrate treatment. Many breast cancer patients will also continue 10-20mg per day indefinitely once the cancer is in remission in order to prevent it from coming back.
We then have the anabolic steroid user. For on cycle gynecomastia prevention 10-20mg per day is the standard range. If this dosing range does not help it is unlikely any dose will and AI’s should strongly be considered.

We’re then left with PCT use. Most PCT plans will begin with Tamoxifen Citrate doses of 40mg per day and will continue at this dose for 2-3 weeks. The dose will then be reduced to 20mg per day and will continue at this dose for 2-3 weeks. For a proper PCT it will often include another SERM Clomiphene Citrate (Clomid). For a full PCT outline please see How to Come off Steroids.