Exemestane
Active substance: Exemestane
Other names: Aromasin, Exemestane, Exedrol
Active half-life: 24 hours
Exemestane is a steroidal Aromatase Inhibitor (AI) that is most commonly known as Aromasin. The primary purpose of use as with most AI’s would be to combat breast cancer in post-menopausal women. Shortly after, the AI would begin to gain a lot of popularity among anabolic steroid users for its ability to protect against estrogenic related side effects. It would also gain a fair amount of popularity in Post Cycle Therapy (PCT) plans among steroid users.
Effects of Exemestane:
In a therapeutic setting, by blocking the aromatase enzyme, Aromasin actively prohibits the cancer from feeding off the hormone necessary to its survival.
Then we have Aromasin as an anti-estrogen for the anabolic steroid user. By understanding its functions and traits you should already understand the effects of Aromasin in this regard. Excess estrogen levels can promote gynecomastia and water retention and possibly high blood pressure as a secondary issue. Regardless of the steroid in question, Aromasin can offer protection from the estrogenic effects.
An important note: Aromasin will have no affect on dihydrotestosterone (DHT) derived anabolic steroids as they do not convert to estrogen. Such steroids cannot lead to gynecomastia or excess water retention; it is impossible. The exception would be Anadrol (Oxymetholone), while a DHT derivative, it carries with it a strong estrogenic nature. However, while estrogenic action is present, the hormone does not aromatize, meaning there is no aromatization for Aromasin to inhibit. The use of an AI will not affect the estrogenicity of Anadrol. For protection from such a steroid, the individual will need to inhibit activation of the estrogenic mechanism, and this will make SERM’s the first line of defense.
The final effects of Aromasin surround its use in a PCT plan. Due to the use of anabolic steroids natural testosterone production is suppressed. The rate of suppression will be dependent on the steroids being used, and to a degree, the total doses, but natural production will be suppressed nonetheless. Most male steroid users are advised to include exogenous testosterone in all their cycles in order to ensure they have enough testosterone to meet their body’s needs.
Once the cycle of steroids is over, while exogenous testosterone protected the individual while on cycle, at the end of the cycle natural production is still suppressed. Natural production will begin again once all the exogenous hormones have cleared the system, but returning to your prior levels pre-cycle will take a lot of time. By implementing a PCT plan, we stimulate natural testosterone production, cut down on the total recovery time and ensure we have enough testosterone for proper bodily functions. This does not bring our total levels back to their previous naturally high state, but it speeds up the recovery and ensures we do not spend a lot of time in a low testosterone state.
Due to the need for a strong PCT and Aromasin carrying extremely strong natural testosterone stimulating properties, this makes it very appealing for this purpose. Due to the slight androgenic nature and moderately decent promotion of IGF-1 this makes it even more appealing. However, we must consider the primary purpose of Aromasin, which is as an anti-estrogen. High levels of estrogen can be problematic, but the hormone is still necessary to our body’s health. It is important in maintaining a proper immune system, as well as in the maintenance of healthy cholesterol levels. Then consider the PCT, which in part is primarily designed to stimulate natural testosterone production, but the overall primary point is to normalize the body. We cannot normalize with low estrogen levels. For a proper PCT that not only stimulates testosterone production but promotes overall normalization, SERM’s should always be your first choice.
Side effects:
